Enter ESBX...

How do parasites disguise to evade our immune system?

It’s all about gene selection. Our latest collaborative work in PNAS identifies a new key player: ESBX.

Using trypanosomes as a model, we found that ESBX coordinates activation and repression of surface antigen genes. This "monoallelic expression" is a fundamental mystery in biology.

We hope these insights into ESBX open new doors for understanding immune evasion and fundamental principles of gene regulation.

Full paper here.