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Publications

 

 

​​2023

Faria J*, Tinti M, Marques CA, Zoltner M, Yoshikawa H, Field MC, Horn D* (2023) An allele-selective inter-chromosomal bridge supports monogenic expression . Nature Communications

*joint corresponding authors

https://pubmed.ncbi.nlm.nih.gov/38081826/

Behind the paper:

https://communities.springernature.com/posts/all-for-one-and-one-for-all-united-we-stand-divided-we-fall-how-does-a-cell-express-only-one-gene-out-of-a-large-gene-family

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Escrivani D, Scheidt V, Tinti M, Faria J, Horn D. Competition among variants is predictable and contributes to the antigenic variation dynamics of African trypanosomes. PLoS Pathogens

https://doi.org/10.1371/journal.ppat.1011530

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​2022

Faria J*, Briggs EM, Black JA, McCulloch R* (2022) Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome. Current Opinion in Microbiology

*joint corresponding authors

https://doi.org/10.1016/j.mib.2022.102209

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Kovářová J, Novotná M, Faria J, Rico E, Wallace C, Zoltner M, Field MC, Horn D. CRISPR/Cas9-based precision tagging of essential genes in bloodstream form African trypanosomes. Mol Biochem Parasitol. 2022 May;249:111476.

doi: 10.1016/j.molbiopara.2022.111476

https://pubmed.ncbi.nlm.nih.gov/35378143/

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2021

Faria J. (2021) A nuclear enterprise: zooming in on nuclear organization and gene expression control in the African trypanosome. Parasitology

 doi.org/10.1017/S0031182020002437

https://pubmed.ncbi.nlm.nih.gov/33407981/

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Faria J, Luzak V, Muller LSM, Brink BG, Hutchinson S, Glover L, Horn D & Siegel TN. (2021) Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes. Nature Microbiology

doi.org/10.1038/s41564-020-00833-4

https://pubmed.ncbi.nlm.nih.gov/33432154/

Behind the paper:

https://microbiologycommunity.nature.com/posts/a-nuclear-enterprise-drives-immune-evasion

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2019

Faria J, Glover L, Hutchinson S, Bohem C, Field MC, Horn D (2019) Monoallelic expression and epigenetic memory sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex. Nature Communications

doi.org/10.1038/s41467-019-10823-8

https://pubmed.ncbi.nlm.nih.gov/31289266/

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2018

Kovarova J, Nagar R, Faria J, Ferguson MAJ, Barrett MP, Horn D (2018) Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei. PLoS Pathogens, doi.org/10.1371/journal.ppat.1007475.

https://pubmed.ncbi.nlm.nih.gov/30589893/

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Jeacock L, Faria J, Horn D (2018) Codon usage bias controls mRNA and protein abundance in the African trypanosome. Elife, 15;7. pii: e32496.

doi: 10.7554/eLife.32496

https://pubmed.ncbi.nlm.nih.gov/29543155/

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Ronin C, Costa DM, Tavares J, Faria J, Ciesielski F, Ciapetti P, Smith TK, MacDougall J, Cordeiro-da-Silva A, Pemberton IK (2018) The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: implications to protein function and drug design. PLoS One, 15;13(3): e0193602.

doi: 10.1371/journal.pone.0193602

https://pubmed.ncbi.nlm.nih.gov/29543820/

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2017

Loureiro I, Faria J, Santarem N, Smith TK, Tavares J, Cordeiro-da-Silva A (2017) Potential drug targets in the pentose phosphate pathway of trypanosomatids. Current Medicinal Chemistry, v25.

doi: 10.2174/0929867325666171206094752

https://pubmed.ncbi.nlm.nih.gov/29210635/

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2016

Faria J, Loureiro I, Santarem N, Cecílio P, Macedo-Ribeiro S, Tavares J, Cordeiro-da-Silva A (2015) Disclosing Ribose-5-Phosphate Isomerase B Essentiality in Trypanosomatids. Scientific Reports, 6: 26937.

doi: 10.1038/srep26937

https://pubmed.ncbi.nlm.nih.gov/27230471/

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2015

Faria J, Loureiro I, Santarem N, Macedo-Ribeiro S, Tavares J, Cordeiro-da-Silva A (2015) Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity. Plos Neglected Tropical Diseases, 10(1): e0004365.

doi: 10.1371/journal.pntd.0004365

https://pubmed.ncbi.nlm.nih.gov/26771178/

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Faria J, Moraes CB, Song R, Pascoalino BS, Lee N, Siqueira-Neto JL, Cruz DJ, Parkinson T, Loset JR, Cordeiro-da-Silva A, Freitas-Junior LH (2015) Drug Discovery for Human African Trypanosomiasis: Identification of Novel Scaffolds by the Newly Developed HTS/Sybr Green Assay for Trypanosoma brucei. Journal of Biomolecular Screening, 20: 70-81.

doi: 10.1177/1087057114556236.

https://pubmed.ncbi.nlm.nih.gov/25342146/

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Loureiro I, Faria J, Clayton C, Macedo-Ribeiro S, Santarém N, Roy N, Cordeiro-da-Silva A, Tavares J (2015) Ribose-5-phosphate Isomerase B Knockdown Compromises Trypanosoma brucei Bloodstream Form Infectivity. Plos Neglected Tropical Diseases, 9: e3430.

doi: 10.1371/journal.pntd.0003430

https://pubmed.ncbi.nlm.nih.gov/25568941/

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Loureiro I, Faria J, Clayton C, Macedo-Ribeiro S, Roy N, Santarém N, Tavares J, Cordeiro-da-Silva A (2015) Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine. Plos Neglected Tropical Diseases, 7: e2578. doi: 10.1371/journal.pntd.0002578

https://pubmed.ncbi.nlm.nih.gov/24340117/

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2009-2012

Silva LR, Valentão P, Faria J, Ferreres F, Sousa C, Gil-Izquierdo A, Pinho BR, Andrade PB (2012) Phytochemical investigations and biological potential screening with cellular and non-cellular models of globe amaranth (Gomphrena globosa L.) inflorescences. Food Chemistry., 135: 756-63.

doi: 10.1016/j.foodchem.2012.05.015

https://pubmed.ncbi.nlm.nih.gov/22868155/

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Pereira DM, Ferreres F, Oliveira JMA, Gaspar L, Faria J, Valentão P, Sottomayor M, Andrade PB. (2010) Pharmacological effects of Catharantus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine, 17: 646-652.

doi: 10.1016/j.phymed.2009.10.008

https://pubmed.ncbi.nlm.nih.gov/19962870/

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Ferreres F, Pereira DM, Valentão P, Oliveira JMA, Faria J, Gaspar L, Sottomayor M, Andrade PA. (2009) Simple and reproducible HPLC–DAD–ESI-MS/MS analysis of alkaloids in Catharanthus roseus roots. Journal of Pharmaceutical and Biomedical Analysis, 51: 65-69.

doi: 10.1016/j.jpba.2009.08.005

https://pubmed.ncbi.nlm.nih.gov/19720492/

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Pereira DM, Faria J, Gaspar L, Valentão P, Andrade PB. (2009) Exploiting Catharanthus roseus roots: source of antioxidants. Food Chemistry, 121: 56-61.

doi:10.1016/j.foodchem.2009.12.002

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Pereira DM, Faria J, Gaspar L, Valentão P, Andrade PB. (2009) Boerhaavia diffusa: Metabolite profiling of a medicinal plant from Nyctaginaceae. Food and Chemical Toxicology, 47: 2142-2149.

doi: 10.1016/j.fct.2009.05.033

https://pubmed.ncbi.nlm.nih.gov/19500634/

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