York Biomedical Research Institute
University of York
Publications
2025
Monti L, Firth G, Faria JRC, Kelly JM, Flint G, Galli S, Maher TE, Di Antonio M (2025) Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions. (under revision)
Lansink LIM, Walther L, Longmore S, Jones M, Dowle A, Faria JRC (2025) Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes. (under revision)
Singh P, Walther L, Cabahug MD, Faria, JRC*, Bryant J* (2025) Parasite genome organization: come together, right now! Trends in Parasitology
*corresponding authors
Escrivani DO, Hutchinson S, Tinti M, Wright JE, Marques CA, Faria JRC, Horn D (2025) A non-coding role for VSG transcripts in allelic exclusion. (Nucleic Acids Research, in press)
Novotna M, Tinti M, Faria JRC, Horn D (2025) Precision edited histone tails disrupt polycistronic gene expression controls in trypanosomes. Nature Communications
2023
Faria J*, Tinti M, Marques CA, Zoltner M, Yoshikawa H, Field MC, Horn D*. (2023) An allele-selective inter-chromosomal bridge supports monogenic expression . Nature Communications
*corresponding authors
Escrivani D, Scheidt V, Tinti M, Faria J, Horn D. (2023) Competition among variants is predictable and contributes to the antigenic variation dynamics of African trypanosomes. PLoS Pathogens
2022
Faria J*, Briggs EM, Black JA, McCulloch R* (2022) Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome. Current Opinion in Microbiology
*corresponding authors
Kovářová J, Novotná M, Faria J, Rico E, Wallace C, Zoltner M, Field MC, Horn D. (2022) CRISPR/Cas9-based precision tagging of essential genes in bloodstream form African trypanosomes. Mol Biochem Parasitol. 2022 May;249:111476.
2021
Faria J. (2021) A nuclear enterprise: zooming in on nuclear organization and gene expression control in the African trypanosome. Parasitology
Faria J*, Luzak V*, Muller LSM, Brink BG, Hutchinson S, Glover L, Horn D & Siegel TN. (2021) Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes. Nature Microbiology
*joint first authors
2019
Faria J, Glover L, Hutchinson S, Bohem C, Field MC, Horn D (2019) Monoallelic expression and epigenetic memory sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex. Nature Communications
2018
Kovarova J, Nagar R, Faria J, Ferguson MAJ, Barrett MP, Horn D (2018) Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei. PLoS Pathogens, doi.org/10.1371/journal.ppat.1007475.
Jeacock L, Faria J, Horn D (2018) Codon usage bias controls mRNA and protein abundance in the African trypanosome. Elife, 15;7. pii: e32496. doi: 10.7554/eLife.32496
Ronin C, Costa DM, Tavares J, Faria J, Ciesielski F, Ciapetti P, Smith TK, MacDougall J, Cordeiro-da-Silva A, Pemberton IK (2018) The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: implications to protein function and drug design. PLoS One, 15;13(3): e0193602. doi: 10.1371/journal.pone.0193602
2017
Loureiro I*, Faria J*, Santarem N, Smith TK, Tavares J, Cordeiro-da-Silva A (2017) Potential drug targets in the pentose phosphate pathway of trypanosomatids. Current Medicinal Chemistry, v25. doi: 10.2174/0929867325666171206094752
*joint first authors
2016
Faria J, Loureiro I, Santarem N, Cecílio P, Macedo-Ribeiro S, Tavares J, Cordeiro-da-Silva A (2016) Disclosing Ribose-5-Phosphate Isomerase B Essentiality in Trypanosomatids. Scientific Reports, 6: 26937. doi: 10.1038/srep26937
2015
Faria J, Loureiro I, Santarem N, Macedo-Ribeiro S, Tavares J, Cordeiro-da-Silva A (2015) Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity. PLoS Neglected Tropical Diseases, 10(1): e0004365.
doi: 10.1371/journal.pntd.0004365
Faria J, Moraes CB, Song R, Pascoalino BS, Lee N, Siqueira-Neto JL, Cruz DJ, Parkinson T, Loset JR, Cordeiro-da-Silva A, Freitas-Junior LH (2015) Drug Discovery for Human African Trypanosomiasis: Identification of Novel Scaffolds by the Newly Developed HTS/Sybr Green Assay for Trypanosoma brucei. Journal of Biomolecular Screening, 20: 70-81.
doi: 10.1177/1087057114556236.
Loureiro I, Faria J, Clayton C, Macedo-Ribeiro S, Santarém N, Roy N, Cordeiro-da-Silva A, Tavares J (2015) Ribose-5-phosphate Isomerase B Knockdown Compromises Trypanosoma brucei Bloodstream Form Infectivity. PLoS Neglected Tropical Diseases, 9: e3430. doi: 10.1371/journal.pntd.0003430
Loureiro I, Faria J, Clayton C, Macedo-Ribeiro S, Roy N, Santarém N, Tavares J, Cordeiro-da-Silva A (2015) Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine. PLoS Neglected Tropical Diseases, 7: e2578. doi: 10.1371/journal.pntd.0002578
2009-2012
Silva LR, Valentão P, Faria J, Ferreres F, Sousa C, Gil-Izquierdo A, Pinho BR, Andrade PB (2012) Phytochemical investigations and biological potential screening with cellular and non-cellular models of globe amaranth (Gomphrena globosa L.) inflorescences. Food Chemistry, 135: 756-63. doi: 10.1016/j.foodchem.2012.05.015
Pereira DM, Ferreres F, Oliveira JMA, Gaspar L, Faria J, Valentão P, Sottomayor M, Andrade PB. (2010) Pharmacological effects of Catharantus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine, 17: 646-652. doi: 10.1016/j.phymed.2009.10.008
Ferreres F, Pereira DM, Valentão P, Oliveira JMA, Faria J, Gaspar L, Sottomayor M, Andrade PA. (2009) Simple and reproducible HPLC–DAD–ESI-MS/MS analysis of alkaloids in Catharanthus roseus roots. Journal of Pharmaceutical and Biomedical Analysis, 51: 65-69. doi: 10.1016/j.jpba.2009.08.005
Pereira DM, Faria J, Gaspar L, Valentão P, Andrade PB. (2009) Exploiting Catharanthus roseus roots: source of antioxidants. Food Chemistry, 121: 56-61. doi:10.1016/j.foodchem.2009.12.002
Pereira DM, Faria J, Gaspar L, Valentão P, Andrade PB. (2009) Boerhaavia diffusa: Metabolite profiling of a medicinal plant from Nyctaginaceae. Food and Chemical Toxicology, 47: 2142-2149. doi: 10.1016/j.fct.2009.05.033