Publications

 

​​2025

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Monti L, Firth G, Faria JRC, Kelly JM, Flint G, Galli S, Maher TE, Di Antonio M (2025) Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions. (under revision) 

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Lansink LIM, Walther L, Longmore S, Jones M, Dowle A, Faria JRC (2025) Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes. (under revision)

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Singh P, Walther L, Cabahug MD, Faria, JRC*, Bryant J* (2025) Parasite genome organization: come together, right now! Trends in Parasitology

*corresponding authors

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Escrivani DO, Hutchinson S, Tinti M, Wright JE, Marques CA, Faria JRC, Horn D (2025) A non-coding role for VSG transcripts in allelic exclusion.  (Nucleic Acids Research, in press)

 

Novotna M, Tinti M, Faria JRC, Horn D (2025) Precision edited histone tails disrupt polycistronic gene expression controls in trypanosomes. Nature Communications

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​​2023

Faria J*, Tinti M, Marques CA, Zoltner M, Yoshikawa H, Field MC, Horn D*. (2023) An allele-selective inter-chromosomal bridge supports monogenic expression . Nature Communications

*corresponding authors

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Behind the paper

News Article

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Escrivani D, Scheidt V, Tinti M, Faria J, Horn D. (2023) Competition among variants is predictable and contributes to the antigenic variation dynamics of African trypanosomes. PLoS Pathogens

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​2022

Faria J*, Briggs EM, Black JA, McCulloch R* (2022) Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome. Current Opinion in Microbiology

*corresponding authors

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Kovářová J, Novotná M, Faria J, Rico E, Wallace C, Zoltner M, Field MC, Horn D. (2022) CRISPR/Cas9-based precision tagging of essential genes in bloodstream form African trypanosomes. Mol Biochem Parasitol. 2022 May;249:111476.

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2021

Faria J. (2021) A nuclear enterprise: zooming in on nuclear organization and gene expression control in the African trypanosome. Parasitology

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Faria J*, Luzak V*, Muller LSM, Brink BG, Hutchinson S, Glover L, Horn D & Siegel TN. (2021) Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes. Nature Microbiology

*joint first authors

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Behind the paper

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2019

Faria J, Glover L, Hutchinson S, Bohem C, Field MC, Horn D (2019) Monoallelic expression and epigenetic memory sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex. Nature Communications

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2018

Kovarova J, Nagar R, Faria J, Ferguson MAJ, Barrett MP, Horn D (2018) Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei. PLoS Pathogens, doi.org/10.1371/journal.ppat.1007475.

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Jeacock L, Faria J, Horn D (2018) Codon usage bias controls mRNA and protein abundance in the African trypanosome. Elife, 15;7. pii: e32496. doi: 10.7554/eLife.32496

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Ronin C, Costa DM, Tavares J, Faria J, Ciesielski F, Ciapetti P, Smith TK, MacDougall J, Cordeiro-da-Silva A, Pemberton IK (2018) The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: implications to protein function and drug design. PLoS One, 15;13(3): e0193602. doi: 10.1371/journal.pone.0193602

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2017

Loureiro I*, Faria J*, Santarem N, Smith TK, Tavares J, Cordeiro-da-Silva A (2017) Potential drug targets in the pentose phosphate pathway of trypanosomatids. Current Medicinal Chemistry, v25. doi: 10.2174/0929867325666171206094752

*joint first authors

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2016

Faria J, Loureiro I, Santarem N, Cecílio P, Macedo-Ribeiro S, Tavares J, Cordeiro-da-Silva A (2016) Disclosing Ribose-5-Phosphate Isomerase B Essentiality in Trypanosomatids. Scientific Reports, 6: 26937. doi: 10.1038/srep26937

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2015

Faria J, Loureiro I, Santarem N, Macedo-Ribeiro S, Tavares J, Cordeiro-da-Silva A (2015) Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity. PLoS Neglected Tropical Diseases, 10(1): e0004365.

doi: 10.1371/journal.pntd.0004365

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Faria J, Moraes CB, Song R, Pascoalino BS, Lee N, Siqueira-Neto JL, Cruz DJ, Parkinson T, Loset JR, Cordeiro-da-Silva A, Freitas-Junior LH (2015) Drug Discovery for Human African Trypanosomiasis: Identification of Novel Scaffolds by the Newly Developed HTS/Sybr Green Assay for Trypanosoma brucei. Journal of Biomolecular Screening, 20: 70-81.

doi: 10.1177/1087057114556236.

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Loureiro I, Faria J, Clayton C, Macedo-Ribeiro S, Santarém N, Roy N, Cordeiro-da-Silva A, Tavares J (2015) Ribose-5-phosphate Isomerase B Knockdown Compromises Trypanosoma brucei Bloodstream Form Infectivity. PLoS Neglected Tropical Diseases, 9: e3430. doi: 10.1371/journal.pntd.0003430

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Loureiro I, Faria J, Clayton C, Macedo-Ribeiro S, Roy N, Santarém N, Tavares J, Cordeiro-da-Silva A (2015) Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine. PLoS Neglected Tropical Diseases, 7: e2578. doi: 10.1371/journal.pntd.0002578

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2009-2012

Silva LR, Valentão P, Faria J, Ferreres F, Sousa C, Gil-Izquierdo A, Pinho BR, Andrade PB (2012) Phytochemical investigations and biological potential screening with cellular and non-cellular models of globe amaranth (Gomphrena globosa L.) inflorescences. Food Chemistry, 135: 756-63. doi: 10.1016/j.foodchem.2012.05.015

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Pereira DM, Ferreres F, Oliveira JMA, Gaspar L, Faria J, Valentão P, Sottomayor M, Andrade PB. (2010) Pharmacological effects of Catharantus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine, 17: 646-652. doi: 10.1016/j.phymed.2009.10.008

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Ferreres F, Pereira DM, Valentão P, Oliveira JMA, Faria J, Gaspar L, Sottomayor M, Andrade PA. (2009) Simple and reproducible HPLC–DAD–ESI-MS/MS analysis of alkaloids in Catharanthus roseus roots. Journal of Pharmaceutical and Biomedical Analysis, 51: 65-69. doi: 10.1016/j.jpba.2009.08.005

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Pereira DM, Faria J, Gaspar L, Valentão P, Andrade PB. (2009) Exploiting Catharanthus roseus roots: source of antioxidants. Food Chemistry, 121: 56-61. doi:10.1016/j.foodchem.2009.12.002

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Pereira DM, Faria J, Gaspar L, Valentão P, Andrade PB. (2009) Boerhaavia diffusa: Metabolite profiling of a medicinal plant from Nyctaginaceae. Food and Chemical Toxicology, 47: 2142-2149. doi: 10.1016/j.fct.2009.05.033